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MANOOL

  • CAS：596-85-0
  • purity：99%
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Reputable manufacturer supply MANOOL 596-85-0 in stock with high standard

  • Molecular Formula: C20H34 O
  • Molecular Weight: 290.489
  • Vapor Pressure: 6.45E-07mmHg at 25°C 
  • Melting Point: 49-52 °C(lit.)
     
  • Boiling Point: 368.2°Cat760mmHg 
  • PKA: 14.47±0.29(Predicted) 
  • Flash Point: 118.2°C 
  • PSA： 20.23000 
  • Density: 0.93g/cm3 
  • LogP: 5.50240 

MANOOL(Cas 596-85-0) Usage

Definition

ChEBI: A labdane diterpenoid in which the labdane skeleton has double bonds at positions 8(17) and 14 and carries an R-hydroxy group at position 13.

Cytotoxicity

IC50 (μg/mL): 49.3 (V79), 15.6 (B16F10),17.1 (MCF-7), 6.7 (HeLa), 28.5 (HepG2),9.6 (MO59 J), 6.7 (U343), 13.1 (U251)(de Oliveira et al. 2016)

InChI:InChI=1/C20H34O/c1-7-19(5,21)14-11-16-15(2)9-10-17-18(3,4)12-8-13-20(16,17)6/h7,16-17,21H,1-2,8-14H2,3-6H3/t16-,17-,19-,20+/m0/s1

596-85-0 Relevant articles

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation, and Untargeted Metabolomics

Crusco, Alessandra,Whiteland, Helen,Baptista, Rafael,Forde-Thomas, Josephine E.,Beckmann, Manfred,Mur, Luis A. J.,Nash, Robert J.,Westwell, Andrew D.,Hoffmann, Karl F.

, p. 1188 - 1199 (2019/06/08)

Sclareol, a plant-derived diterpenoid wi...

A short and efficient synthesis of (+)-totarol

Rogachev, Victor,Loehl, Thorsten,Markert, Thomas,Metz, Peter

, p. 172 - 180 (2013/09/24)

A concise route to multigram quantities ...

Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis

Hoshino, Tsutomu,Nakano, Chiaki,Ootsuka, Takahiro,Shinohara, Yosuke,Hara, Takashi

experimental part, p. 2156 - 2165 (2011/05/14)

The Rv3378c gene product from Mycobacter...

Oxidation studies on 8(17),14-labdadien-3R,13R-diol: A major diterpene of Juniperus pseudosabina Hook

Agarwal, S. G.,Thappa, R. K.,Dhar, K. L.

, p. 669 - 671 (2007/10/03)

The renewable foerest biomass of Juniper...

596-85-0 Process route

Toluene-4-sulfonic acid (2R,4aR,5S,8aR)-5-((S)-3-hydroxy-3-methyl-pent-4-enyl)-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

Toluene-4-sulfonic acid (2R,4aR,5S,8aR)-5-((S)-3-hydroxy-3-methyl-pent-4-enyl)-1,1,4a-trimethyl-6-methylene-decahydro-naphthalen-2-yl ester

(+)-manool
596-85-0,29461-42-5,41357-91-9,106631-38-3,1438-62-6

(+)-manool

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran;
82%
(E,E,E)-geranylgeranyl diphosphate
6699-20-3,13100-78-2,64732-91-8

(E,E,E)-geranylgeranyl diphosphate

(+)-manool
596-85-0,29461-42-5,41357-91-9,106631-38-3,1438-62-6

(+)-manool

manool
596-85-0

manool

8<sup>(17)</sup>,13(E)-labdadien-15-ol
10395-43-4

8(17) ,13(E)-labdadien-15-ol

Conditions
Conditions Yield
With DL-dithiothreitol; recombinant (+)-copalyl diphosphate synthase-GST fusion protein; recombinant Rv3378c enzyme from Mycobacterium tuberculosis; magnesium chloride; at 30 ℃; for 15h; pH=7.5; diastereoselective reaction; aq. buffer; Enzymatic reaction;
40%
15%
12%

596-85-0 Upstream products

  • 147802-35-5
    147802-35-5

    3-oxo-8(17) -labdadien-13R-ol

  • 515-03-7
    515-03-7

    sclareol

  • 131889-10-6
    131889-10-6

    8(17) -labdadien-3R,13R-diol

  • 6699-20-3
    6699-20-3

    (E,E,E)-geranylgeranyl diphosphate

596-85-0 Downstream products

  • 16633-27-5
    16633-27-5

    (Z)-3-Methyl-5-((1S,4aS)-5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-pent-2-enal

  • 16633-27-5
    16633-27-5

    (E)-3-Methyl-5-((1S,4aS)-5,5,8a-trimethyl-2-methylene-decahydro-naphthalen-1-yl)-pent-2-enal

  • 6697-24-1
    6697-24-1

    isopimara-8,15-diene

  • 18319-61-4
    18319-61-4

    Δ8(9) -pimaradiene

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