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Quality Manufacturer Supply High Purity 99% N-Methyl-D-aspartic acid 6384-92-5 with Reasonable Price
- Molecular Formula: C5H9NO4
- Molecular Weight: 147.131
- Appearance/Colour: white to off-white crystalline powder
- Vapor Pressure: 0.0042mmHg at 25°C
- Melting Point: 187-192 °C
- Refractive Index: -15 ° (C=2, H2O)
- Boiling Point: 258.237 °C at 760 mmHg
- PKA: 2.21±0.23(Predicted)
- Flash Point: 109.978 °C
- PSA: 86.63000
- Density: 1.343 g/cm3
- LogP: -0.47540
N-Methyl-D-aspartic acid(Cas 6384-92-5) Usage
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Biological Activity |
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset? . |
|
Biochem/physiol Actions |
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy. |
|
references |
[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7. |
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Definition |
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration. |
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General Description |
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase. |
InChI:InChI=1/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1
6384-92-5 Relevant articles
Caged Bioactive Carboxylates. Synthesis, Photolysis Studies, and Biological Characterization of a New Caged N-Methyl-D-aspartic Acid
Gee, Kyle R.,Niu, Li,Schaper, Klaus,Hess, George P.
, p. 4260 - 4263 (1995)
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Preparation method of nitrogen-substituted aspartic acid
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Paragraph 0054; 0055; 0056; 0057; 0058; 0059; 0060-0062, (2019/01/24)
The invention discloses a preparation me...
Pig growth urges the medicinal preparation preparation method of gene expression (by machine translation)
-
, (2017/08/30)
The invention discloses a Pig growth gen...
Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides
Kwan, Jason C.,Ratnayake, Ranjala,Abboud, Khalil A.,Paul, Valerie J.,Luesch, Hendrik
experimental part, p. 8012 - 8023 (2011/03/20)
Grassypeptolides A-C (1-3), a group of c...
6384-92-5 Process route
-
-
1010433-25-6
grassypeptolide A
-
-
2623-91-8
(R)-2-aminobutyric acid
-
-
24830-94-2,134357-96-3,7013-32-3,82822-12-6
D-allo-threonine
-
-
2480-23-1
N-methyl-L-valine
-
-
6384-92-5
N-methyl-D-aspartate
-
-
498-40-8,3024-83-7
L-Cysteic acid
-
-
35554-98-4,3024-83-7
D-Cysteic acid
-
-
4226-18-0
N-methyl-L-aspartic acid
-
-
147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L -proline
| Conditions | Yield |
|---|---|
|
grassypeptolide A;
With
ozone;
at 20 ℃;
for 0.5h;
oxidative conditions;
|
-
-
1256936-18-1
grassypeptolide C
-
-
2623-91-8
(R)-2-aminobutyric acid
-
-
24830-94-2,134357-96-3,7013-32-3,82822-12-6
D-allo-threonine
-
-
2480-23-1
N-methyl-L-valine
-
-
6384-92-5
N-methyl-D-aspartate
-
-
498-40-8,3024-83-7
L-Cysteic acid
-
-
35554-98-4,3024-83-7
D-Cysteic acid
-
-
4226-18-0
N-methyl-L-aspartic acid
-
-
147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L -proline
| Conditions | Yield |
|---|---|
|
grassypeptolide C;
With
ozone;
at 20 ℃;
for 0.5h;
oxidative conditions;
|
6384-92-5 Upstream products
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1783-96-6
(2R)-aspartic acid
-
77-78-1
dimethyl sulfate
-
74-88-4
methyl iodide
-
17833-53-3
N-methyl-DL-aspartic acid
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