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N-Methyl-D-aspartic acid

  • CAS:6384-92-5
  • purity:99%
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Quality Manufacturer Supply High Purity 99% N-Methyl-D-aspartic acid 6384-92-5 with Reasonable Price

  • Molecular Formula: C5H9NO4
  • Molecular Weight: 147.131
  • Appearance/Colour: white to off-white crystalline powder 
  • Vapor Pressure: 0.0042mmHg at 25°C 
  • Melting Point: 187-192 °C 
  • Refractive Index: -15 ° (C=2, H2O) 
  • Boiling Point: 258.237 °C at 760 mmHg 
  • PKA: 2.21±0.23(Predicted) 
  • Flash Point: 109.978 °C 
  • PSA: 86.63000 
  • Density: 1.343 g/cm3 
  • LogP: -0.47540 

N-Methyl-D-aspartic acid(Cas 6384-92-5) Usage

Biological Activity

Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset? .

Biochem/physiol Actions

Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy.

references

[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7.

Definition

ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration.

General Description

N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.

InChI:InChI=1/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/p-1/t3-/m1/s1

6384-92-5 Relevant articles

Caged Bioactive Carboxylates. Synthesis, Photolysis Studies, and Biological Characterization of a New Caged N-Methyl-D-aspartic Acid

Gee, Kyle R.,Niu, Li,Schaper, Klaus,Hess, George P.

, p. 4260 - 4263 (1995)

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Preparation method of nitrogen-substituted aspartic acid

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Paragraph 0054; 0055; 0056; 0057; 0058; 0059; 0060-0062, (2019/01/24)

The invention discloses a preparation me...

Pig growth urges the medicinal preparation preparation method of gene expression (by machine translation)

-

, (2017/08/30)

The invention discloses a Pig growth gen...

Grassypeptolides A-C, cytotoxic bis-thiazoline containing marine cyclodepsipeptides

Kwan, Jason C.,Ratnayake, Ranjala,Abboud, Khalil A.,Paul, Valerie J.,Luesch, Hendrik

experimental part, p. 8012 - 8023 (2011/03/20)

Grassypeptolides A-C (1-3), a group of c...

6384-92-5 Process route

grassypeptolide A
1010433-25-6

grassypeptolide A

(R)-2-aminobutyric acid
2623-91-8

(R)-2-aminobutyric acid

D-allo-threonine
24830-94-2,134357-96-3,7013-32-3,82822-12-6

D-allo-threonine

N-methyl-L-valine
2480-23-1

N-methyl-L-valine

N-methyl-D-aspartate
6384-92-5

N-methyl-D-aspartate

L-Cysteic acid
498-40-8,3024-83-7

L-Cysteic acid

D-Cysteic acid
35554-98-4,3024-83-7

D-Cysteic acid

N-methyl-L-aspartic acid
4226-18-0

N-methyl-L-aspartic acid

<i>L</i>-proline
147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7

L -proline

Conditions
Conditions Yield
grassypeptolide A; With ozone; at 20 ℃; for 0.5h;
oxidative conditions;
grassypeptolide C
1256936-18-1

grassypeptolide C

(R)-2-aminobutyric acid
2623-91-8

(R)-2-aminobutyric acid

D-allo-threonine
24830-94-2,134357-96-3,7013-32-3,82822-12-6

D-allo-threonine

N-methyl-L-valine
2480-23-1

N-methyl-L-valine

N-methyl-D-aspartate
6384-92-5

N-methyl-D-aspartate

L-Cysteic acid
498-40-8,3024-83-7

L-Cysteic acid

D-Cysteic acid
35554-98-4,3024-83-7

D-Cysteic acid

N-methyl-L-aspartic acid
4226-18-0

N-methyl-L-aspartic acid

<i>L</i>-proline
147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7

L -proline

Conditions
Conditions Yield
grassypeptolide C; With ozone; at 20 ℃; for 0.5h;
oxidative conditions;

6384-92-5 Upstream products

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    methyl iodide

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    17833-53-3

    N-methyl-DL-aspartic acid

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