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Reboxetine

  • CAS：98769-81-4
  • purity：99%
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Quality products?make an important contribution to long-term revenue and profitability. Factory Sells Best Quality Reboxetine 98769-81-4 with GMP standards

1.What is the Reboxetine ?

(2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one
93886-32-9,98769-79-0,98769-80-3,98819-75-1

(2RS,3RS)-6-<α-(2-ethoxyphenoxy)benzyl>morpholin-3-one

reboxetine
71620-89-8,71621-36-8,93851-86-6,98769-81-4,98769-83-6,98819-76-2,105017-38-7

reboxetine

Conditions
Conditions Yield
With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 4h; Yield given; Ambient temperature;
With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 10 ℃; for 0.25h; Large scale;
trans-2,3-epoxy-3-phenylpropan-1-ol
40641-81-4

trans-2,3-epoxy-3-phenylpropan-1-ol

reboxetine
71620-89-8,71621-36-8,93851-86-6,98769-81-4,98769-83-6,98819-76-2,105017-38-7

reboxetine

Conditions
Conditions Yield
Multi-step reaction with 8 steps
1: 1.) NaOH / 1.) H2O, 70 deg C; 2.) H2O, 70 deg C, 2.5 h
2: 61 percent / pyridine / 2 h / -10 °C
3: 84 percent / Et3N / CH2Cl2 / 0.5 h / 0 - 5 °C
4: 2N NaOH / dioxane / 4 h / Ambient temperature
5: 32percent NH4OH / methanol / 6 h / sealed flask
6: 98 percent / Et3N / CH2Cl2 / 0.5 h / -10 - -5 °C
7: 86 percent / t-BuOK / 2-methyl-propan-2-ol / 3 h / Ambient temperature
8: RED-AL / toluene / 4 h / Ambient temperature
With ammonium hydroxide; sodium hydroxide; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,4-dioxane; pyridine; methanol; dichloromethane; toluene; tert-butyl alcohol;
Multi-step reaction with 10 steps
1: sodium hydroxide; methyl tributylammonium chloride / water / 4 h / 60 °C / Large scale
2: triethylamine / ethyl acetate / 0.42 h / -15 °C
3: triethylamine / ethyl acetate / 0.25 h / -15 °C
4: hydrogenchloride / water; ethyl acetate / 0.5 h / 15 - 25 °C
5: sodium hydroxide; methyl tributylammonium chloride / water / 2 h / 20 - 25 °C / Large scale
6: ammonium hydroxide / methanol / 3 h / 40 °C / Large scale
7: dichloromethane; isopropyl alcohol / 5 h / Large scale
8: triethylamine; carbonic acid dimethyl ester / 0.5 h / 4 - 10 °C / Large scale
9: potassium tert-butylate / isopropyl alcohol; tert-butyl alcohol / 1 h / 20 °C / Large scale
10: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 0.25 h / 10 °C / Large scale
With hydrogenchloride; ammonium hydroxide; potassium tert-butylate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; methyl tributylammonium chloride; carbonic acid dimethyl ester; sodium hydroxide; In methanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; toluene; tert-butyl alcohol;

2.What is the CAS number for Reboxetine ?

The CAS number of Reboxetine is 98769-81-4.

More information of Reboxetine 98769-81-4 are:

CAS?Number

 98769-81-4

Melting Point

 170-171°

Boiling Point

 443.7°C at 760 mmHg

Flash Point

 188.2°C

Vapor Pressure

 4.54E-08mmHg at 25°C

PSA

 39.72000

LogP

 3.52260

3.What are another words for Reboxetine ?

Synonyms?for?Reboxetine 98769-81-4:REBOXETINE;(2R)-2-[(R)-(2-Ethoxyphenoxy)phenylmethyl]morpholine

4.What is the molecular formula of Reboxetine?

The chemical formula of ?Reboxetine is?C19H23NO3 which containing 19 Carbon atoms,23 Hydrogen atoms,1 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of??Reboxetine?is 313.397.

5.What is Reboxetine (98769-81-4) used for?

Reboxetine is a pure noradrenaline reuptake inhibitor that is licensed as an antidepressant in the United Kingdom. Reboxetine has established efficacy based on placebo-controlled studies both in the short and the long term. Previous noradrenaline reuptake inhibitors, such as desipramine, nortriptyline, and maprotiline, have been relatively selective for noradrenaline compared with serotonin but have not avoided affinities with α1, muscarinic, and histaminergic receptors. The lack of selectivity of these drugs has the consequence that the levels of cardiotoxicity are those expected with TCAs. Reboxetine is the first pure noradrenaline reuptake inhibitor, and therefore it may also provide a more appropriate agent to consider for the investigation of possible adjunctive treatments with SSRIs.

InChI:InChI=1/C19H23NO3.CH4O3S/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18;1-5(2,3)4/h3-11,18-20H,2,12-14H2,1H3;1H3,(H,2,3,4)

Relevant articles related to Reboxetine:

Article

Source

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Page/Page column 171, (2019/05/09)

Stereodivergent synthesis of all the four stereoisomers of antidepressant reboxetine

Liu, Cheng,Lin, Zhi-Wei,Zhou, Zhao-Hui,Chen, Hong-Bin

, p. 5395 - 5401 (2017/07/10)

6.Buy Reboxetine with the best price .

Tianjin Puck Rice Chemicals Co., Ltd. is a quality supplier of Reboxetine. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Reboxetine 98769-81-4.

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